New publication online: M-12, an additional metabolite of MCI/MI

A new analytical method was developed in the BMU/VCI cooperation

Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are broadly used conserving agents.

To further evaluate the exposure of the population towards MCI/MI a new method for analysing the metabolite M-12 was developed in a project on the advancement of human biomonitoring in Germany agreed by the German Ministry for the Environment (BMU) and the German Chemical Industry Association (VCI).
A first small batch of urine samples of the German Environmental Specimen Bank (ESB) was analysed with this method and the results are published in a scientific journal.

This was preceded by studies of the main metabolite of MCI/MI, N-methylmalonamic acid, in the same samples in 2019.

To the publication Quantification of a mercapturate metabolite of the biocides methylisothiazolinone and chloromethylisothiazolinone (“M-12”) in human urine using online-SPE-LC/MS/MS