Mixture of phthalate diesters differing slightly in branching of the alcohol chains and main substitute of DEHP as plasticizer
diisononyl phthalate (DiNP) denominates a group of several phthalate diesters with slightly different branching of the alcohol chains. They are produced by esterification of phthalic acid with iso-nonyl alcohol. DiNP 1 (CAS 68515-48-0) is produced by the so called
polygas process and contains more or less equal amounts of 3,4-, 4,6-, 3,6-, 3,5-, 4,5-, und 5,6-dimethyl heptanol-1. DiNP 2 (CAS 28553-12-0) is based on n-butene and its alcohol fraction consists mainly of alkyl substituted octanols, heptanols and hexanols. Active profiles and toxicology of both DiNP are very similar. For regulatory purposes they are therefore handled as one.
DiNP is a plasticizer mainly for PVC and is present for instance in floorings and wall coverings, carpets, shoe soles, tubes, cables and vinyl gloves. Further applications include rubber, dispersions, paints, lacquers, sealants, adhesives and packaging.
It is increasingly used as substitute of DEHP (diethylhexyl phthalate).
DiNP is not chemically bound in the polymer matrix and may outgas or be released upon contact with fluids or fats. When it enters the environment it is readily degraded. DiNP has a relatively high potential for bioaccumulation.
By precautionary principles the use of DiNP in toys has been forbidden, although no threats of human health has been proven so far.
For the Environmental Specimen Bank not the parent compound DiNP itself is analysed in human specimens but its major metabolites.
7oxo-MiNPMono(4-methyl-7-oxo-octyl)phthalate is a oxidised DiNP metabolite with functional oxo group.
7OH-MiNPMono(4-methyl-7-hydroxyoctyl)phthalate is a oxidised DiNP metabolite with functional hydroxyl group.
7cx-MiNPMono(4-methyl-7-carboxyheptyl)phthalate is a oxidised DiNP metabolite with functional carboxyl-group.
Student groups with an even number of female and male students at the age of 20 to 29.
1988 - 2015
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Internal phthalate exposure over the last two decades – A retrospective human biomonitoring study
Wittassek, Matthias; Wiesmüller, Gerhard A.; Koch, Holger M.; Eckard, Rolf; Dobler, Lorenz; Helm, Dieter; Müller, Johannes; Angerer, Jürgen; Schlüter, Christoph
International Journal of Hygiene and Environmental Health 210 (2007), 3-4, 319-333, 2007