Mixture of phthalate diesters differing slightly in branching of the alcohol chains and main substitute of DEHP as plasticizer
diisononyl phthalate (DiNP) denominates a group of several phthalate diesters with slightly different branching of the alcohol chains. They are produced by esterification of phthalic acid with iso-nonyl alcohol. DiNP 1 (CAS 68515-48-0) is produced by the so called
polygas process and contains more or less equal amounts of 3,4-, 4,6-, 3,6-, 3,5-, 4,5-, und 5,6-dimethyl heptanol-1. DiNP 2 (CAS 28553-12-0) is based on n-butene and its alcohol fraction consists mainly of alkyl substituted octanols, heptanols and hexanols. Active profiles and toxicology of both DiNP are very similar. For regulatory purposes they are therefore handled as one.
DiNP is a plasticizer mainly for PVC and is present for instance in floorings and wall coverings, carpets, shoe soles, tubes, cables and vinyl gloves. Further applications include rubber, dispersions, paints, lacquers, sealants, adhesives and packaging.
It is increasingly used as substitute of DEHP (diethylhexyl phthalate).
DiNP is not chemically bound in the polymer matrix and may outgas or be released upon contact with fluids or fats. When it enters the environment it is readily degraded. DiNP has a relatively high potential for bioaccumulation.
In chronic animal tests DiNP is toxic. Furthermore, toxicity on reproduction can not be excluded.
By precautionary principles the use of DiNP in toys has been forbidden, although no threats of human health has been proven so far.
For the Environmental Specimen Bank not the parent compound DiNP itself is analysed in human specimens but its major metabolites.
7oxo-MiNPMono(4-methyl-7-oxo-octyl)phthalate is a oxidised DiNP metabolite with functional oxo group.
7OH-MiNPMono(4-methyl-7-hydroxyoctyl)phthalate is a oxidised DiNP metabolite with functional hydroxyl group.
7cx-MiNPMono(4-methyl-7-carboxyheptyl)phthalate is a oxidised DiNP metabolite with functional carboxyl-group.
Student groups with an even number of female and male students at the age of 20 to 29.
1988 - 2015
Links to external information and legislation
- Commission Communication on the results of the risk evaluation and the risk reduction strategies for the substances: Dibutylphthalate; 3,4-Dichloroaniline; Di-'isodecyl' phthalate; 1,2-Benzenedicarboxylic acid, di-C9-11-branched alkyl esters, C10-rich; Di-'isononyl' phthalate; 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich; Ethylenediaminetetraacetate; Methyl acetate; Monochloroacetic acid; n-Pentane; Tetrasodium ethylenediaminetetraacetate (2006/C 90/04)
- Directive 2005/84/EC of the European Parliament and of the Council of 14 December 2005 amending for the 22nd time Council Directive 76/769/EEC on the approximation of the laws, regulations and administrative provisions of the Member States relating to restrictions on the marketing and use of certain dangerous substances and preparations (phthalates in toys and childcare articles)
- Directive 2013/39/EU of the European Parliament and of the Council of 12 August 2013 amending Directives 2000/60/EC and 2008/105/EC as regards priority substances in the field of water policy
- Begründung für Bewertung von Stoffeigenschaften: Diisononylphthalat (DINP) (German)
Internal phthalate exposure over the last two decades – A retrospective human biomonitoring study
Wittassek, Matthias; Wiesmüller, Gerhard A.; Koch, Holger M.; Eckard, Rolf; Dobler, Lorenz; Helm, Dieter; Müller, Johannes; Angerer, Jürgen; Schlüter, Christoph
International Journal of Hygiene and Environmental Health 210 (2007), 3-4, 319-333, 2007