Important substitute for phthalates
Due to the increased regulation of phthalates, Hexamoll® DINCH® has been used as a plasticizer since 2002, mainly as a DEHP (di (2-ethylhexyl) phthalate) substitute in toys and medical equipment. Due to its similar structure (the aromatic ring of the phthalates is replaced by a cyclohexane ring) it possesses similar physical properties but shows far lower toxicity. The high demand for phthalate species leads to a strong increase in the use and production of DINCH®.
MINCHCyclohexane-1,2-dicarboxylate-mono-4-methyloctyl ester is the primary metabolite of DINCH® after elimination of an ester rest.
OH-MINCHCyclohexane-1,2-dicarboxylate-mono-(7-hydroxy-4-methyl)octyl ester is a secondary metabolite of DINCH®.
oxo-MINCHCyclohexane-1,2-dicarboxylate-mono(oxo-isononyl) ester is a secondary metabolite of DINCH®.
cx-MINCHCyclohexane-1,2-dicarboxylate-mono-(7-carboxylate-4-methyl) heptylester is a secondary metabolite of DINCH®.
Student groups with an even number of female and male students at the age of 20 to 29.
4 university cities as sampling areas.
1999 - 2017
Links to external information and legislation
Entering markets and bodies: increasing levels of the novel plasticizer Hexamoll® DINCH® in 24 hr urine samples from the German Environmental Specimen Bank
Schütze, André; Kolossa-Gehring, Marike; Apel, Petra; Brüning, Thomas; Koch, Holger M.
International Journal of Hygiene and Environmental Health (2013), online 16 August 2013, 2013
Time trend of exposure to the phthalate plasticizer substitute DINCH in Germany from 1999 to 2017: Biomonitoring data on young adults from the Environmental Specimen Bank (ESB)
Kasper-Sonnenberg, Monika; Koch, Holger M.; Apel, Petra; Rüther, Maria; Pälmke, Claudia; Brüning, Thomas; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health (2019), online 1 August 2019, 2019