Hexamoll DINCH

Important substitute for phthalates

Due to the increased regulation of phthalates, Hexamoll DINCH has been used as a plasticizer since 2002, mainly as a DEHP (di (2-ethylhexyl) phthalate) substitute in toys and medical equipment. Due to its similar structure (the aromatic ring of the phthalates is replaced by a cyclohexane ring) it possesses similar physical properties but shows far lower toxicity. The high demand for phthalate species leads to a strong increase in the use and production of DINCH.

Substances

• MINCH

  Cyclohexane-1,2-dicarboxylate-mono-4-methyloctyl ester is the primary metabolite of DINCH® after elimination of an ester rest.

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• OH-MINCH

  Cyclohexane-1,2-dicarboxylate-mono-(7-hydroxy-4-methyl)octyl ester is a secondary metabolite of DINCH®.

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• oxo-MINCH

  Cyclohexane-1,2-dicarboxylate-mono(oxo-isononyl) ester is a secondary metabolite of DINCH®.

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• cx-MINCH

  Cyclohexane-1,2-dicarboxylate-mono-(7-carboxylate-4-methyl) heptylester is a secondary metabolite of DINCH®.

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Specimen

• Students

  Student groups with an even number of female and male students at the age of 20 to 29.

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Sampling area

Sampling period

Extended information

Links to external information and legislation

• Stoffmonographie für 1,2-Cyclohexandicarbonsäuredi-isononylester (Hexamoll® DINCH®) – HBM-Werte für die Summe der Metabolite Cyclohexan-1,2-dicarbonsäuremono-hydroxyisononylester  (OH-MINCH) und Cyclohexan-1,2- dicarbonsäure-mono-carboxyisooctylester (cx-MINCH) im Urin von Erwachsenen und Kindern (PDF, external source) (external)

Literature

• Entering markets and bodies: increasing levels of the novel plasticizer Hexamoll® DINCH® in 24 hr urine samples from the German Environmental Specimen Bank
  Schütze, André; Kolossa-Gehring, Marike; Apel, Petra; Brüning, Thomas; Koch, Holger M.
  International Journal of Hygiene and Environmental Health (2013), online 16 August 2013, 2013
  
• Time trend of exposure to the phthalate plasticizer substitute DINCH in Germany from 1999 to 2017: Biomonitoring data on young adults from the Environmental Specimen Bank (ESB)
  Kasper-Sonnenberg, Monika; Koch, Holger M.; Apel, Petra; Rüther, Maria; Pälmke, Claudia; Brüning, Thomas; Kolossa-Gehring, Marike
  International Journal of Hygiene and Environmental Health (2019), online 1 August 2019, 2019