Blood plasma

Ideal matrix for most chemicals because it is in contact with the whole organism and in equilibrium with the organs and tissues in that chemicals are being accumulated

Blood plasma is the liquid component of blood and serves as transport medium for the blood cells and for many substances like metabolic products, lipids, glucose, proteins, hormones, minerals, oxygen and carbon dioxide. It accounts for about 55 % of the whole blood. In contrast to serum, blood plasma still contains all coagulation factors.

In clinical diagnostics blood plasma is the most important body fluid. Essential trace and bulk elements are homeostatically regulated. Because of its lipid content, blood plasma can be used for concentration analysis of organic lipophilic xenobiotics. Depending on distribution of a substance between blood plasma and cell-compartment of the blood must be decided whether analyses in whole blood or blood plasma make sense.

For more information about the specimen, the sampling and the processing of samples see the Guideline for Sampling and Sample Processing Whole Blood and Blood Plasma (2015) - IBMT.

For investigations in the years 2011 to 2014 you will find the regulations in Richtlinie zur Probenahme und Probenbearbeitung Vollblut und Blutplasma (2011) - UKM.

Recommended analysis examples

• Hexachlorobenzene in blood plasma of students from Münster

Sampling area

Analytes

• Metals

  Eighty percent of all elements on earth are metals

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• Nonmetals

  Only eighteen elements in the periodic table

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• Chlorohydrocarbons

  Group of organic compounds with at least one covalently bonded chlorine atom

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• Per- and polyfluoroalkyl compounds

  Organic compounds which are fully (per-) or partially (poly-) fluorinated

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• Flame Retardants

  Flame retardants reduce the flammability of objects

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• Supplementary parameters

  Additional information for the interpretation of contamination data

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Sampling period

Extended information

Literature

• Retrospective monitoring of perfluorocarboxylates and perfluorosulfonates in human plasma archived by the German Environmental Specimen Bank
  Schröter-Kermani, Christa; Müller, Josef; Jürling, Heinrich; Conrad, André; Schulte, Christoph
  International Journal of Hygiene and Environmental Health 216 (2013), 6, 633-640, 2013
  
• The Environmental Specimen Bank for Human Tissues as part of the German Environmental Specimen Bank
  Wiesmüller, G.A.; Eckard, R; Dobler, L.; Günsel, A.; Oganowski, M.; Schröter-Kermani, C.; Schlüter, C.; Gies, A.; Kemper, F. H.
  International Journal of Hygiene and Environmental Health 210 (2007), 3-4, 299-305, 2007