Methylisothiazolinone and Methylchloroisothiazolinone
2-Methyl-4-isothiazolin-3-one, 5-Chloro-2-methyl-4-isothiazolin-3-one, MI, MCI, Kathon CG®, ACTICIDE® SPX; formula (MI): C4H5NOS; CAS Registry Number (MI): 2682-20-4; formula (MCI): C4H4ClNOS; CAS Registry Number (MCI/MI): 55965-84-9
Preservatives, that are used alone (MI) or in combination (MCI/MI)
Because of their antimicrobial properties, Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) are used as preservatives in paints and varnishes but also in hygiene and cleaning products. No regulation was put on the maximum amount of MI or a combination of MI and MCI in industrial products and cleaning products. In contrast the use in cosmetics is regulated (Commission Regulation (EU) 1224/2017).
Both MI and MCI are classified as contact allergens.
The metabolite of both substances (MI and MCI), N-methylmalonamic acid, is used for the human biomonitoring analyses.
N-Methyl malonamic acidThe common metabolite of Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI)
Student groups with an even number of female and male students at the age of 20 to 29.
2000 - 2017
Links to external information and legislation
- Commission Regulation (EU) 2017/1224 of 6 July 2017 amending Annex V to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products (Text with EEA relevance.)
N-methylmalonamic acid (NMMA) as metabolite of methylisothiazolinone and methylchloroisothiazolinone in 24-h urine samples of the German Environmental Specimen Bank from 2000 to 2017 - exposure and time trends
Schettgen, Thomas; Rüther, Maria; Weber, Till; Kraus, Thomas; Kolossa-Gehring, Marike
Chemosphere (2019), 125743; online 27 December 2019, 2019